50 Cent is the Masta of the Hip hop world in my opinion. Throughout the entire song the guitar plays this: Main Riff:
e[---------------------------]
B[---------------------------]
G[---------------------------]
D[---------------------------]
A[---11/12--9/11--12\11------]
E[---------------------------]
Repeat, repeat, and then repeat some more.
Source: http://www.azchords.com/0-9/50cent-tabs-43/indaclub-tabs-67908.html